Remi Walter's 69th-minute penalty gave Nice a third straight home win as Lyon lost 1-0 to end a five-game winning streak in all competitions.
Cesc Fabregas struck the winner for struggling Monaco in a much-needed 2-1 win against Toulouse in Ligue 1 on Saturday.
Edinson Cavani struck twice as Paris Saint-Germain continued their march towards the Ligue 1 title with a 4-1 home thrashing of Stade Rennais.
Substitute Moussa Dembele fired a last-gasp winner as Lyon came from behind to defeat St Etienne 2-1 in the Derby Rhone-Alpes.
Montpellier missed the chance to move up to third place in Ligue 1 after being held to a 1-1 draw at relegation-threatened Dijon on Sunday.
Paris Saint-Germain saw their 43-match winning run in domestic cup competitions come to an end after a shock 2-1 home defeat by Guingamp.
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