Barcelona moved three points clear at the top of La Liga following an impressive 4-0 win at derby rivals Espanyol.
Denis Suarez struck twice for Copa del Rey holders Barcelona as they thrashed Cultural Leonesa 4-1 on Wednesday to progress to the last 16 5-1 on aggregate.
Iago Aspas scored twice as Celta Vigo got back on track in La Liga with a 2-0 victory over Huesca.
Santiago Solari strengthened his case to land the Real Madrid job permanently after leading them to a 4-2 win at Celta Vigo.
The January transfer window is just three weeks away meaning clubs across Europe are hastily trying to put the finishing touches to deals.
Alaves missed the chance to go second in La Liga after conceding an injury-time goal in a fiery 2-1 defeat to Basque rivals Eibar.
Sevilla and Alaves moved level on points with Atletico Madrid - and one point behind leaders Barcelona - in La Liga after fighting back for victories.
Atletico Madrid bounced back from their worst defeat under coach Diego Simeone by beating Real Sociedad 2-0.
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